Wednesday, December 28, 2011

At the bench (Part 1)

We smile, we cry, we laugh, we get mad, we sulk and at times we just walk around with a straight face. Your face speaks for your mind. That is the power of our nature of expression. Apparently some folks have an extremely subtle nature of expressing themselves such that it takes a hefty chunk of patience and monetary investment to actually see through it.

Alright, I’ll cut underestimating these folks by masking our inefficiency to read them with accuracy and precision. My work here as a fellow, is to study the expression of a crucial protein which hops around in our body, assisting the production of important steroids in our system. We shall call him StAR. Oh yeah! I bet he is one. Not only because, this protein governs the rate-limiting step in the steroidogenic process, but also because it is the acronym for its long name – Steroidogenic Acute Regulatory protein. So that’s our StAR shining brightly in our adrenal, gonadal and every al(l) other cells that generate steroids. Steroids (in the form of hormones) are what drives you to metabolise pretty much all that you take in, mediate your behavioural responses, maintain your ionic pool, make a girl a girl and a boy a boy etc etc. Due to StAR’s cardinal role in the steroidal synthesis it is quite simple to infer that elevated expression of this protein corresponds to an up-regulation of steroidogenesis. Correspondingly, doing the math for low protein expression is no rocket science.

So why am I fiddling with StAR so much? Few studies suggest that Round up a monopolized herbicide by Monsanto widely used in the market has an adverse effect on the steroidogenic process in mammals. This is likely to jack the adrenal and gonadal steroid hormone production and believe me, you don’t want that. In our work, we treat our cute yet ill-fated rats with this herbicide at different concentrations of and study StAR’s expression in the adrenal cells with respect to this treatment, which according to some pioneers in the reproductive endocrinology domain does drop and if our study substantiates their claims, then D-Uh! Monsanto’s gonna party in hell!! :P (Ok, that was a li’l too exaggerated....this biggie can gobble anything :/ )

The very 1st scrap...

When I sit for an exam, even before the answer sheet is distributed, its a scrap sheet I ask for. If someone begins a new venture, the first thing one would likely do is invoke the almighty going omm namoh blah blah but I start with frantically pacing around looking for a scrap sheet. For me, a scrap sheet is the seed for every tree I plant. I'm sure its the same for many others too. This blog is a more or less a diary...a science diary punched with myriad of such scrap sheets I pick up along my journey as tiny little neophyte budding in this big fat world ruled by science.

My life revolves around science, my science revolve around life. So do not sulk or be surprised if you find bulk scraps blaring out biology in this blog. Scientific experiences, papers, links, write ups, articles anything and everything sciencilicious to me is all that is stacked up here. And what good is it going to bring out to the world?? Baah! I would have never started this if I was to sit and hunt for an answer to that.

Cheers!